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2012年北京市常住人口麻疹抗体水平调查
作者:李娟 卢莉 陈萌 黄芳 曾阳 李晓梅 马蕊 潘静彬 孙穆 孙昊 王中占 郭舫如 张一华 王凤双 吴涛 崔德军 彭兴慧 吴疆 庞星火
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摘要:

   目的了解北京市常住人口麻疹抗体水平。方法  2012年在北京市城区和郊区选择连续居住6个月以上的10个年龄组人群作为调查对象,共2125名。采用调查问卷收集调查对象的人口学特征、麻疹患病史、含麻疹成分疫苗免疫史,并采集静脉血5 ml。使用ELISA检测研究对象麻疹IgG抗体水平。结果  调查对象麻疹抗体阳性率为8471%(1800/2125),标化阳性率为8807%,抗体水平中位数为96046 IU/L。不同年龄组人群中,麻疹抗体阳性率和抗体水平差异均具有统计学意义(χ2=34160,P<001;H=21627,P<001),其中,1岁以下婴儿最低,抗体阳性率和抗体水平中位数分别为4306%(90/209)、18580 IU/L;1~4岁和5~9岁儿童较高,分别为9731%(181/186)、9646%(218/226)和244881、191072 IU/L;15岁及以上人群抗体阳性率在8198%~9014%之间,抗体水平在74438~147484 IU/L之间。本市人口麻疹抗体阳性率和抗体水平分别为8245%(883/1071)、89982 IU/L,低于流动人口的8700%(917/1054)和116619 IU/L,差异有统计学意义(χ2=851,P<001;U=538 70400,P<001)。既往接种过含麻疹成分疫苗的人群抗体阳性率和抗体水平分别为9195%(891/969)、144311 IU/L,高于既往未接种疫苗和免疫史不详的人群[分别为3295(57/173)和12733 IU/L,8667%(852/983)和92373 IU/L],差异有统计学意义(χ2=39992,P<001;H=20211,P<001)。结论  北京市常住人口中,1~9岁儿童麻疹抗体水平较高,发生大范围麻疹暴发和流行的风险较小,<1岁婴儿和15~40岁本市和流动人口麻疹抗体水平有待进一步提高。

关键词:麻疹;抗体;疫苗;免疫

Abstract:

   ObjectiveTo analyze the measles immunity level of persistent population in BeijingMethods  A total of 2125 objects from 10 age groups,who had been living in Beijing for over 6 months,were selected from urban and rural areas in Beijing in 2012Demographic characteristics,history of measles and vaccine immunization were investigated by questionnaire5 ml blood sample of each subject was collected,and the Measles IgG antibody was measured by ELISA assayResults  Positive rate of measles antibody was 8471%(1800/2125) and standardized positive rate was 8807% Median of antibody was 96046 IU/LPositive rate and median of measles antibody were significantly different between population from different age groups  (χ2=34160,P<001; H=21627,P<001) Antibody positive rate and median were lowest in the <1 year age group,which were separately 4306%(90/209) and 18580 IU/L; and highest in the 1-4 (9731%(181/186) and 244881 IU/L) and 5-9 years age group (9646%(218/226) and 191072 IU/L)The range of antibody positive rate and median in adults of ≥15 years were 8198%-9014% and 74438-147484 IU/LAntibody positive rate and median in persistent population,which were separately 8245%(883/1071) and 89982 IU/L,were lower than those in migrant population,which were 8700%(917/1054) and 16619 IU/L,respectively (χ2=851,P<001;U=538 70400,P<001)Antibody positive rate and median in population with vaccination history,which were separately 9195%(891/969) and 144311 IU/L,were higher than those population without vaccination history and people whose history unknown (3295%(57/173),12733 IU/L; 8667%(852/983),92373 IU/L)The difference showed statistical significance (χ2=39992,P<001; H=20211,P<001).Conclusion  Among the persistent population in China,measles antibody level among the children aging 1-9 years old was high enough to prevent outbreak and epidemic of measlesHowever,we should try our best to strengthen the measles antibody level among the babies younger than 1 year old and the migrant population aging between 15 and 40 years old

Key words: Measles;Antibodies;Vaccines;Immunity

发表日期:2013/10

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参考文献:

[1] 汤杰麻疹抗体血清学研究现状公共卫生与预防医学,2010,21(5):4849
[2] 傅传喜,梁建华,张伟,等广州市2001—2004年健康人群麻疹抗体水平监测分析疾病控制杂志,2006,10(5):540542
[3] 陆培善,邓秀英,胡莹,等江苏省2006—2008年健康人群麻疹抗体监测分析江苏预防医学,2010,21(3):1921
[4] 李娟,卢莉,刘东磊,等2005—2010年北京市麻疹流行病学特征与消除麻疹措施分析疾病监测,2012,27(5):353357
[5] 李娟,卢莉,马蕊,等北京市2010年麻疹减毒活疫苗补充免疫活动前后麻疹流行病学特征变化中国疫苗和免疫,2013,19(1):3134
[6] 朱毓卉,许青,李秀君,等山东省一岁以下婴儿麻疹病例时空分布特征分析中华预防医学杂志,2012,46(10):898902
[7] 王凤英,吴晓虹,陈志清浙江省金华市本地及外来人群麻疹抗体水平监测分析疾病监测,2010,14(7):546548
[8] 高洁,朱小珍上海市静安区健康人群麻疹抗体水平调查中华疾病控制杂志,2010,14(7):641643
[9] 赵艳荣,陈恩富,李倩,等有麻疹减毒活疫苗接种史的麻疹病例流行病学分析中国疫苗和免疫,2011,17(4):326329

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