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中国八省份一般人群血和尿中锰、钴、钼水平分布的研究
作者:潘亚娟 丁春光 张爱华 吴邦华 黄汉林 朱醇 刘徳晔 朱宝立 许光 邵华 彭珊茁 姜先龙 赵春香 韩长城 姬红蓉 余善法 张晓曦 张龙连 郑玉新 闫慧芳

摘要:

目的调查我国一般人群血和尿中锰、钴、钼水平,分析其人群分布特点。方法20092010年,在我国东部、西部和中部8个省份的24个市县,采用整群随机抽样的方法抽取了18 1206~60岁人群为研究对象,对其生活习惯和健康状况进行了问卷调查,并分别采集其静脉抗凝血样和尿样。用电感耦合等离子体质谱法对血样和尿样进行锰、钴、钼含量检测,通过统计学分析不同年龄、性别人群血和尿中锰、钴、钼水平的分布。结果我国一般人群血锰几何均数为8.98 μg/L,男性和女性血锰几何均数分别为8.149.88 μg/LZ=-18.84P<0.01);尿锰几何均数为0.63 μg/L,男性和女性尿锰几何均数分别为0.620.63 μg/LZ=-0.67P0.05;血钴几何均数为0.194 μg/L,男性和女性血钴几何均数分别为0.1660.225 μg/LZ=-23.04P<0.01);尿钴几何均数为0.282 μg/L,男性和女性尿钴几何均数分别为0.2600.307 μg/LZ=-7.35P<0.01);血钼几何均数为0.25 μg/L,男性和女性血钼几何均数分别为0.270.23 μg/LZ=-5.03P<0.01);尿钼几何均数为27.7 μg/L,男性和女性尿钼几何均数分别为29.825.6 μg/LZ=-6.31P<0.01)。结论我国一般人群血和尿中锰、钴、钼水平存在性别及地区差异。

关键词:锰;钴;钼;血液;尿;电感藕合等离子体质谱

Abstract:

ObjectiveTo evaluated the manganese(Mn), cobalt (Co) and molybdenum (Mo) levels in blood and urine among general population in China, and thereby to analyze their prevalent features.MethodsFrom 2009 to 2010, a total of 18 120 subjects of general population aged 6~60 years were recruited from 24 districts in 8 provinces in eastern, central and western China mainland, by cluster random sampling method.The information about their living environment and health status were collected by questionnaire, and their blood and urine samples were also collected.Inductive coupled plasma mass spectrometry (ICP~MS) was applied to test the Mn, Co and Mo levels of blood and urine samples, and the Mn, Co, Mo distribution in blood and urine among groups of population in different ages and genders were then analyzed.ResultsAmong general population in China, the geometric mean (GM) of Mn concentration in blood was 8.98 μg/L.The Mn concentration in blood among males and females were separately 8.14 μg/L and 9.88 μg/L (Z=-18.84P<0.01).The GM of Mn concentration in urine was 0.63 μg/L.The Mn concentration in urine among males and females were separately 0.62 μg/L and 0.63 μg/L (Z=-0.67P0.05).The geometric mean (GM) of Co concentration in blood was 0.194 μg/L.The Co concentration in blood among males and females were separately 0.166 μg/L and 0.225 μg/L (Z=-23.04P<0.01).The GM of Co concentration in urine was 0.282 μg/L.The Co concentration in urine among males and females were separately 0.260 μg/L and 0.307 μg/L (Z=-7.35P<0.01).The GM of Mo concentration in blood was 0.25 μg/L.The Mo concentration in blood among male and female group were separately 0.27 μg/L and 0.23 μg/L (Z=-5.03P<0.01).The GM of Mo concentration in urine was 27.7 μg/L.The Mo concentration in urine among males and females were 29.8 μg/L and 25.6 μg/L (Z=-6.31P<0.01), respectively.ConclusionThe Mn, Co and Mo levels in blood and urine varied by gender and area among general population in China, the study provided basic data evidence for the following Mn, Co and Mo biological monitoring studies in near future.

Key words: Manganese;Cobalt;Molybdenum;Blood;Urine;Inductive coupled plasma mass spectrometry

发表日期:2014/9

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