首页 >>2014年09期
儿童肥胖遗传易感性研究现状
作者:张美仙 米杰

摘要:

关键词:

Abstract:

Key words:

发表日期:2014/9

引用本文:

图/表:

  • 10.3760/cma.j.issn.0253-9624.2014.09.019.T001:表1 全基因组关联研究发现的与BMI存在关联(P<5×10–8)的基因位点

    10.3760/cma.j.issn.0253-9624.2014.09.019.T001:表1 全基因组关联研究发现的与BMI存在关联(P<5×10–8)的基因位点

  • 10.3760/cma.j.issn.0253-9624.2014.09.019.T002:表2 全基因组关联研究发现的与腰臀比存在关联(P<5×10–8)的基因位点

    10.3760/cma.j.issn.0253-9624.2014.09.019.T002:表2 全基因组关联研究发现的与腰臀比存在关联(P<5×10–8)的基因位点

  • 10.3760/cma.j.issn.0253-9624.2014.09.019.T003:表3 全基因组关联研究发现的与肥胖存在关联(P<5×10–8)的基因位点

    10.3760/cma.j.issn.0253-9624.2014.09.019.T003:表3 全基因组关联研究发现的与肥胖存在关联(P<5×10–8)的基因位点

参考文献:

[1]NgM, FlemingT, RobinsonM, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013[J]. Lancet, 2014, In press.
[2]WangY, LimH. The global childhood obesity epidemic and the association between socio-economic status and childhood obesity[J]. Int Rev Psychiatry, 2012, 24(3):176–188.
[3]OgdenCL, CarrollMD, KitBK, et al. Prevalence of childhood and adult obesity in the United States, 2011-2012[J]. JAMA, 2014, 311(8):806–814.
[4]马军, 蔡赐河, 王海俊, 等. 1985–2010年中国学生超重与肥胖流行趋势[J]. 中华预防医学杂志, 2012, 46(9):776–780.
[5]HermanKM, CraigCL, GauvinL, et al. Tracking of obesity and physical activity from childhood to adulthood: The physical activity longitudinal study[J]. Int J Pediatr Obes, 2009, 4(4):281–288.
[6]RankinenT, ZuberiA, ChagnonYC, et al. The human obesity gene map: the 2005 update[J]. Obesity (Silver Spring), 2006, 14(4):529–644.
[7]SaundersCL, ChiodiniBD, ShamP, et al. Meta-analysis of genome-wide linkage studies in BMI and obesity[J]. Obesity (Silver Spring), 2007, 15(9):2263–2275.
[8]FraylingTM, TimpsonNJ, WeedonMN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity[J]. Science, 2007, 316(5826):889–894.
[9]LoosRJ, LindgrenCM, LiS, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity[J]. Nat Genet, 2008, 40(6):768–775.
[10]SpeliotesEK, WillerCJ, BerndtSI, et al. Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index[J]. Nat Genet, 2010, 42(11):937–948.
[11]ThorleifssonG, WaltersGB, GudbjartssonDF, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity[J]. Nat Genet, 2009, 41(1):18–24.
[12]WillerCJ, SpeliotesEK, LoosRJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation[J]. Nat Genet, 2009, 41(1):25–34.
[13]OkadaY, KuboM, OhmiyaH, et al. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations[J]. Nat Genet, 2012, 44(3):302–306.
[14]WenW, ChoYS, ZhengW, et al. Meta-analysis identifies common variants associated with body mass index in east Asians[J]. Nat Genet, 2012, 44(3):307–311.
[15]MondaKL, ChenGK, TaylorKC, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry[J]. Nat Genet, 2013, 45(6):690–696.
[16]LindgrenCM, HeidIM, RandallJC, et al. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution[J]. PLoS Genet, 2009, 5(6):e1000508.
[17]HeidIM, JacksonAU, RandallJC, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution[J]. Nat Genet, 2010, 42(11):949–960.
[18]BerndtSI, GustafssonS, M?giR, et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture[J]. Nat Genet, 2013, 45(5):501–512.
[19]GraffM, NgwaJS, WorkalemahuT, et al. Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course[J]. Hum Mol Genet, 2013, 22(17):3597–3607.
[20]PeiYF, ZhangL, LiuY, et al. Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity[J]. Hum Mol Genet, 2014, 23(3):820–830.
[21]YangJ, LoosRJ, PowellJE, et al. FTO genotype is associated with phenotypic variability of body mass index[J]. Nature, 2012, 490(7419):267–272.
[22]ChoYS, GoMJ, KimYJ, et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits[J]. Nat Genet, 2009, 41(5):527–534.
[23]JiaoH, ArnerP, HoffstedtJ, et al. Genome wide association study identifies KCNMA1 contributing to human obesity[J]. BMC Med Genomics, 2011, 4:51.
[24]BradfieldJP, TaalHR, TimpsonNJ, et al. A genome-wide association meta-analysis identifies new childhood obesity loci[J]. Nat Genet, 2012, 44(5):526–531.
[25]WangK, LiWD, ZhangCK, et al. A genome-wide association study on obesity and obesity-related traits[J]. PLoS One, 2011, 6(4):e18939.
[26]MeyreD, DelplanqueJ, ChèvreJC, et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations[J]. Nat Genet, 2009, 41(2):157–159.
[27]SandholtCH, HansenT, PedersenO. Beyond the fourth wave of genome-wide obesity association studies[J]. Nutr Diabetes, 2012, 2:e37.
[28]WangJ, ThorntonJC, RussellM, et al. Asians have lower body mass index (BMI) but higher percent body fat than do whites: comparisons of anthropometric measurements[J]. Am J Clin Nutr, 1994, 60(1):23–28.
[29]HeW, ZhangS, SongA, et al. Greater abdominal fat accumulation is associated with higher metabolic risk in Chinese than in white people: an ethnicity study[J]. PLoS One, 2013, 8(3):e58688.
[30]Croteau-ChonkaDC, MarvelleAF, LangeEM, et al. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women[J]. Obesity (Silver Spring), 2011, 19(5):1019–1027.
[31]KangSJ, ChiangCW, PalmerCD, et al. Genome-wide association of anthropometric traits in African- and African-derived populations[J]. Hum Mol Genet, 2010, 19(13):2725–2738.
[32]NgMC, HesterJM, WingMR, et al. Genome-wide association of BMI in African Americans[J]. Obesity (Silver Spring), 2012, 20(3):622–627.
[33]LuY, LoosRJ. Obesity genomics: assessing the transferability of susceptibility loci across diverse populations. Genome Med, 2013, 5(6):55.
[34]LoosRJ. Genetic determinants of common obesity and their value in prediction[J]. Best Pract Res Clin Endocrinol Metab, 2012, 26(2):211–226.
[35]HaworthCM, CarnellS, MeaburnEL, et al. Increasing heritability of BMI and stronger associations with the FTO gene over childhood[J]. Obesity (Silver Spring), 2008, 16(12):2663–2668.
[36]LajunenHR, KaprioJ, Keski-RahkonenA, et al. Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins[J]. Int J Obes (Lond), 2009, 33(5):559–567.
[37]SilventoinenK, RokholmB, KaprioJ, et al. The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies[J]. Int J Obes (Lond), 2010, 34(1):29–40.
[38]Pietil?inenKH, KaprioJ, RissanenA, et al. Distribution and heritability of BMI in Finnish adolescents aged 16y and 17y: a study of 4884 twins and 2509 singletons[J]. Int J Obes Relat Metab Disord, 1999, 23(2):107–115.
[39]WardleJ, CarnellS, HaworthCM, et al. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment[J]. Am J Clin Nutr, 2008 , 87(2):398–404.
[40]den HoedM, EkelundU, BrageS, et al. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies[J]. Diabetes, 2010, 59(11):2980–2988.
[41]MeiH, ChenW, JiangF, et al. Longitudinal replication studies of GWAS risk SNPs influencing body mass index over the course of childhood and adulthood[J]. PLoS One, 2012, 7(2):e31470.
[42]HallmanDM, FriedelVC, EissaMA, et al. The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents[J]. Int J Obes (Lond), 2012, 36(1):61–68.
[43]MeiH, ChenW, MillsK, et al. Influences of FTO gene on onset age of adult overweight[J]. Hum Genet, 2012, 131(12):1851–1859.
[44]SchousboeK, WillemsenG, KyvikKO, et al. Sex differences in heritability of BMI: a comparative study of results from twin studies in eight countries[J]. Twin Res, 2003, 6(5):409–421.
[45]WangJ, MeiH, ChenW, et al. Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty[J]. Int J Obes(Lond), 2012, 36(4):542–547.
[46]ZillikensMC, YazdanpanahM, PardoLM, et al. Sex-specific genetic effects influence variation in body composition[J]. Diabetologia, 2008, 51(12):2233–2241.
[47]HaberstickBC, LessemJM, McQueenMB, et al. Stable genes and changing environments: body mass index across adolescence and young adulthood[J]. Behav Genet, 2010, 40(4):495–504.
[48]HongJ, ShiJ, QiL, et al. Genetic susceptibility, birth weight and obesity risk in young Chinese[J]. Int J Obes (Lond), 2013, 37(5):673–677.
[49]XiB, ShenY, ZhangM, et al. The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China[J]. BMC Med Genet, 2010, 11:107.
[50]WuL, XiB, ZhangM, et al. Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children[J]. Diabetes, 2010, 59(12):3085–3089.
[51]XiB, ShenY, ReillyKH, et al. Sex-dependent associations of genetic variants identified by GWAS with indices of adiposity and obesity risk in a Chinese children population[J]. Clin Endocrinol (Oxf), 2013, 79(4):523–528.
[52]XiB, ChengH, ShenY, et al. Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children[J]. PLoS One, 2013, 8(2):e56472.
[53]ZhaoX, XiB, ShenY, et al. An obesity genetic risk score is associated with metabolic syndrome in Chinese children[J]. Gene, 2014, 535(2):299–302.
[54]XiB, WangC, WuL, et al. Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity[J]. Am J Epidemiol, 2011, 173(11):1256–1262.
[55]HoranM, GibneyE, MolloyE, et al. Methodologies to assess paediatric adiposity[J]. Ir J Med Sci, 2014, In press.
[56]J??skel?inenA, SchwabU, KolehmainenM, et al. Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986[J]. PLoS One, 2013, 8(9):e73802.
[57]J??skel?inenT, PaananenJ, Lindstr?mJ, et al. Genetic predisposition to obesity and lifestyle factors--the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study[J]. Br J Nutr, 2013, 110(10):1856–1865.
[58]Kilpel?inenTO, QiL, BrageS, et al. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218, 166 adults and 19, 268 children[J]. PLoS Med, 2011, 8(11):e1001116.
[59]RendoT, MoleresA, Marti Del MoralA. Effects of the FTO gene on lifestyle intervention studies in children[J]. Obes Facts, 2009, 2(6):393–399.
[60]RothCL, HinneyA, SchurEA, et al. Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention[J]. BMC Pediatr, 2013, 13:197.
[61]ReinehrT, WoltersB, RothCL, et al. FTO gene: association to weight regain after lifestyle intervention in overweight children[J]. Horm Res Paediatr, 2014, In press.
[62]ZlatohlavekL, VrablikM, MotykovaE, et al. FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention[J]. Clin Biochem, 2013, 46(4/5):313–316.

用户评论 0条

用户名: 密码: 登陆 注册
 
  • 9
  • 3
  •  4 : 页次:0/0页 共0条记录 5条/每页
    关于我们 | 专家风采 | 会员注册 | 继续教育
    地 址:北京市西城区东河沿街69号正弘大厦511室 邮 编:100052
    电话:010-51322302
    版权所有 中华医学会及中华预防医学杂志编辑部
    京ICP备 07035254 号