首页 >>2016年03期
人群三氯生暴露水平研究进展
作者:金辰烨 陈依明 张佩祺 熊哲祯 王彩凤 田英

摘要:

三氯生是一种广谱抗菌物质,国外已在人群中普遍检出该物质,尿液、血液及乳汁等样本中检出率高。我国的人群暴露水平报道较少,人群尿液三氯生水平低于美国人群。截至目前,人体三氯生暴露的影响因素尚未明确,但已有研究表明,青壮年、家庭收入和社会地位较高者的尿液三氯生浓度偏高,而性别、国家和地域、遗传、代谢和生活方式等方面的差异也可能引起三氯生暴露水平的差异。

关键词:三氯生;环境暴露;人口学特征

Abstract:

Triclosan, a broad-spectrum antimicrobial agent, was reported to have been widely detected in various human biological samples such as urine, blood and human milk among foreign populations. In China, limited reports have been found on human exposure to triclosan, and the reported urinary triclosan concentrations were significantly lower than that of American populations. Besides, the potential influencing factors still remain unclear regarding human exposure to triclosan, but evidences suggest that those in middle age and with higher household income and higher social class tend to have higher urinary triclosan concentrations. Furthermore, triclosan exposure tend to differ by sex, geography, heredity, metabolism and life style.

Key words: Triclosan;Environmental exposure;Demographic characteristics

发表日期:2016/3

引用本文:

图/表:

    暂无图表

参考文献:

[1]LiaoC, KannanK. A Survey of Alkylphenols, Bisphenols, and Triclosan in Personal Care Products from China and the United States[J]. Arch Environ Contam Toxicol, 2014, 67(1):50-59. DOI: 10.1007/s00244-014-0016-8.
[2]Sandborgh-EnglundG, Adolfsson-EriciM, OdhamG, et al. Pharmacokinetics of Triclosan Following Oral Ingestion in Humans[J]. J Toxicol Environ Health A, 2006, 69(20):1861-1873. DOI:10.1080/15287390600631706.
[3]QueckenbergC, MeinsJ, WachallB, et al. Absorption, Pharmacokinetics, and Safety of Triclosan after Dermal Administration[J]. Antimicrob Agents Chemother, 2010, 54(1):570-572. DOI: 10.1128/AAC.00615-09.
[4]FrederiksenH, JensenTK, J?rgensenN, et al. Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012[J]. Reproduction, 2014, 147(4):555-565. DOI: 10.1530/REP-13-0522.
[5]LiX, YingGG, ZhaoJL, et al. 4-Nonylphenol, bisphenol-A and triclosan levels in human urine of children and students in China, and the effects of drinking these bottled materials on the levels[J]. Environ Int, 2013, 52:81-86. DOI: 10.1016/j.envint.2011.03.026.
[6]ChenM, TangR, FuG, et al. Association of exposure to phenols and idiopathic male infertility[J]. J Hazard Mater, 2013, 250-251:115-121. DOI: 10.1016/j.jhazmat.2013.01.061.
[7]PirardC, SagotC, DevilleM,et al. Urinary levels of bisphenol A, triclosan and 4-nonylphenol in a general Belgian population[J]. Environ Int, 2012, 48:78-83. DOI: 10.1016/j.envint.2012.07.003.
[8]FrederiksenH, NielsenJK, M?rckTA, et al. Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother-child pairs[J]. Int J Hyg Environ Health, 2013, 216(6):772-783. DOI: 10.1016/j.ijheh.2013.02.006.
[9]CalafatAM, YeX, WongLY, et al. Urinary Concentrations of Triclosan in the U.S. Population: 2003-2004[J]. Environ Health Perspect, 2008, 116(3):303-307. DOI: 10.1289/ehp.10768.
[10]EngelLS, BuckleyJP, YangG, et al. Predictors and variability of repeat measurements of urinary phenols and parabens in a cohort of shanghai women and men[J]. Environ Health Perspect, 2014, 122(7):733-740. DOI: 10.1289/ehp.1306830.
[11]WolffMS, TeitelbaumSL, WindhamG, et al. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls[J]. Environ Health Perspect, 2007, 115(1):116-121.
[12]WolffMS, EngelSM, BerkowitzGS, et al. Prenatal phenol and phthalate exposures and birth outcomes[J]. Environ Health Perspect, 2008, 116(8):1092-1097. DOI: 10.1289/ehp.11007.
[13]PyckeBF, GeerLA, DalloulM, et al. Human fetal exposure to triclosan and triclocarban in an urban population from brooklyn, New York[J]. Environ Sci Technol, 2014, 48(15):8831-8838. DOI: 10.1021/es501100w.
[14]KimK, ParkH, YangW, et al. Urinary concentrations of bisphenol A and triclosan and associations with demographic factors in the Korean population[J]. Environ Res, 2011, 111(8):1280-1285. DOI: 10.1016/j.envres.2011.09.003.
[15]CasasL, FernándezMF, LlopS, et al. Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children[J]. Environ Int, 2011, 37(5):858-866.DOI: 10.1016/j.envint.2011.02.012.
[16]ArbuckleTE, MarroL, DavisK, et al. Exposure to free and conjugated forms of bisphenol A and triclosan among pregnant women in the MIREC cohort[J]. Environ Health Perspect,2015, 123(4):277-284. DOI: 10.1289/ehp.1408187.
[17]BertelsenRJ, EngelSM, JuskoTA, et al. Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women[J]. J Expo Sci Environ Epidemiol, 2014, 24(5):517-521. DOI: 10.1038/jes.2013.95.
[18]Centers for Disease Control and Prevention. Fourth National Report on Human Exposure to Environmental Chemicals[EB/OL]. [2015-6-26].http://www.cdc.gov/exposurereport/pdf/fourthreport.pdf.
[19]AllmyrM, HardenF, TomsLM,et al. The influence of age and gender on triclosan concentrations in Australian human blood serum[J]. Sci Total Environ, 2008, 393(1):162-167. DOI: 10.1016/j.scitotenv.2007.12.006.
[20]AllmyrM, Adolfsson-EriciM, McLachlanMS,et al. Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products[J]. Sci Total Environ, 2006, 372(1):87-93. DOI:10.1016/j.scitotenv.2006.08.007.
[21]YeX, ZhouX, WongLYet al. Concentrations of bisphenol A and seven other phenols in pooled sera from 3-11year old children:2001-2002 National Health and Nutrition Examination Survey[J]. Environ Sci Technol, 2012, 46(22):12664-12671. DOI: 10.1021/es303109c.
[22]TomsLM, AllmyrM, MuellerJF, et al. Triclosan in individual human milk samples from Australia[J]. Chemosphere, 2011, 85(11):1682-1686. DOI: 10.1016/j.chemosphere.
[23]王浩,尹杰,张晶,等.北京市母乳中人工合成麝香暴露水平研究[J].卫生研究, 2011, 40(5):605-607.
[24]KrishnanK, GagnéM, NongA,et al. Biomonitoring Equivalents for triclosan[J]. Regul Toxicol Pharmacol, 2010, 58(1):10-17. DOI: 10.1016/j.yrtph.2010.06.004.
[25]ClaytonEM, ToddM, DowdJBet al. The Impact of Bisphenol A and Triclosan on Immune Parameters in the U.S. Population, NHANES 2003-2006[J].Environ Health Perspect, 2011, 119(3):390-396. DOI: 10.1289/ehp.1002883.
[26]BertelsenRJ, LongneckerMP, L?vikM, et al. Triclosan Exposure and Allergic Sensitization in Norwegian children[J]. Allergy, 2013, 68(1):84-91. DOI: 10.1111/all.12058.
[27]SavageJH, MatsuiEC, WoodRA, et al. Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization[J]. J Allergy Clin Immunol, 2012, 130(2):453-460. DOI: 10.1016/j.jaci.2012.05.006.
[28]KoeppeES, FergusonKK, ColacinoJA, et al. Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007-2008[J]. Sci Total Environ, 2013, 445-446:299-305. DOI: 10.1016/j.scitotenv.2012.12.052.
[29]VélezMP, ArbuckleTE, FraserWD. Female exposure to phenols and phthalates and time to pregnancy: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study[J]. Fertil Steril, 2015, 103(4):1011-1020. DOI: 10.1016/j.fertnstert.2015.01.005.
[30]MoosRK, AngererJ, WittsiepeJ, et al. Rapid determination of nine parabens and seven other environmental phenols in urine samples of German children and adults[J]. Int J Hyg Environ Health, 2014, 217(8):845-853. DOI: 10.1016/j.ijheh.2014.06.003.

用户评论 0条

用户名: 密码: 登陆 注册
 
  • 9
  • 3
  •  4 : 页次:0/0页 共0条记录 5条/每页
    关于我们 | 专家风采 | 会员注册 | 继续教育
    地 址:北京市西城区东河沿街69号正弘大厦511室 邮 编:100052
    电话:010-51322302
    版权所有 中华医学会及中华预防医学杂志编辑部
    京ICP备 07035254 号